I was able to install the motherboard into the Tuniq 3 without removing the Core Fan rail first, however it is a very tight squeeze and depending on component placement this may not be possible. The top fan bracket is adjustable and can be moved out of the way if you can get the screw out, which will be difficult with the rail still mounted in place.
The plastic footer can be taken off by first removing two screws, one at the front and one at the rear, and then prying on these tabs. So it is possible to get the Core Fan rail out but it takes some extra steps.
Once the motherboard is in place, the fans can be adjusted or moved to a position that best suits the hardware you have installed. For example, if you have a high-end video card, obviously the lower fan will be in the way when in its default perpendicular position. But it can be moved to the other set of holes on the rail where it is placed parallel to the motherboard and hangs over the video card, providing extra air blowing down over it. The upper fan can also be angled to blow air over the memory slots, processor and/or chipset.
The tool-less riser tabs and drive locks work flawlessly, I had absolutely no problems with either of these. The provided rails also hold hard drives securely in place with a very positive snap lock that prevents them from coming back out. There is only space for three drives. This is a mid-tower design so three is often all you commonly see.
On to final thoughts and conclusion.