Installation of this card is very simple, as with any other graphics card. It takes a direct power connection from your PSU, which is standard for PCI-e cards. It should not be too big for any case you own, but it is a hassle that it takes up two slots.
One problem I noticed, however, is that the card does not sit properly in the PCI slot. As you can see here, it does not fit properly in the back side of the case and therefore does not click into place. I researched this issue in vain on the forums for my motherboard at MSI and for my case at NZXT, but the few people who had experienced such problems had resorted to brute force, a method that did not work for me. I also tried to contact ATi customer support, however, it took them weeks to respond to my query with a simple “I don't know.” This whole fiasco ended up being very disappointing. All-in-all, the ATi customer support is very lacking. I have tried contacting them multiple times, all of which did nothing to help my issues. Their online knowledge base is also lacking and hard to navigate. It is definitely one of ATi's weak points.
The drivers for this card installed easily and the card was up and running without a fuss. The ATi Catalyst Control Center is probably familiar to most of you, but for those of you who have only used nVidia, it is nice how it brings everything together in one place and disappointing how most of its features are already accessible by right-clicking on your desktop.